Posts Tagged ‘music’

Copper Connected to Alzheimer’s Disease

Tuesday, September 3rd, 2013

Proceedings of the National Academy of Sciences of the United States of America has conducted a study linking the consumption of copper to Alzheimer’s:

Significance
The causes of the sporadic form of Alzheimer’s disease (AD) are unknown. In this study we show that copper (Cu) critically regulates low-density lipoprotein receptor-related protein 1–mediated Aβ clearance across the blood–brain barrier (BBB) in normal mice. Faulty Aβ clearance across the BBB due to increased Cu levels in the aging brain vessels may lead to accumulation of neurotoxic Aβ in brains. In a mouse model of AD low levels of Cu also influences Aβ production and neuroinflammation. Our study suggests that Cu may also increase the severity of AD.

Abstract
Whereas amyloid-β (Aβ) accumulates in the brain of normal animals dosed with low levels of copper (Cu), the mechanism is not completely known. Cu could contribute to Aβ accumulation by altering its clearance and/or its production. Because Cu homeostasis is altered in transgenic mice overexpressing Aβ precursor protein (APP), the objective of this study was to elucidate the mechanism of Cu-induced Aβ accumulation in brains of normal mice and then to explore Cu’s effects in a mouse model of Alzheimer’s disease. In aging mice, accumulation of Cu in brain capillaries was associated with its reduction in low-density lipoprotein receptor-related protein 1 (LRP1), an Aβ transporter, and higher brain Aβ levels. These effects were reproduced by chronic dosing with low levels of Cu via drinking water without changes in Aβ synthesis or degradation. In human brain endothelial cells, Cu, at its normal labile levels, caused LRP1-specific down-regulation by inducing its nitrotyrosination and subsequent proteosomal-dependent degradation due in part to Cu/cellular prion protein/LRP1 interaction. In APPsw/0 mice, Cu not only down-regulated LRP1 in brain capillaries but also increased Aβ production and neuroinflammation because Cu accumulated in brain capillaries and, unlike in control mice, in the parenchyma. Thus, we have demonstrated that Cu’s effect on brain Aβ homeostasis depends on whether it is accumulated in the capillaries or in the parenchyma. These findings should provide unique insights into preventative and/or therapeutic approaches to control neurotoxic Aβ levels in the aging brain.

In a separate study, playing a musical instrument was found to and years to the life of the brain.

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Sound Prenatal Learning

Tuesday, August 27th, 2013

by NIH

Many pregnant women read to their bellies, others play music. And now Finnish researchers have found that an early introduction to sound may be a powerful way to stimulate speech and language development later on.

In a small study, researchers followed 33 women from their 29th week of pregnancy until birth. Half of the mothers listened to a recorded pseudoword TATATA repeated hundreds of times each week, sometimes pronounced differently, sometimes with a different pitch.

After birth, all of the babies were exposed to the pseudoword to see if they reacted. Infants who were exposed to the pseudoword in the womb showed a significant response to it reacting more strongly to the word, its pronunciation and pitch changes than newborns who weren’t exposed to the same stimuli.

Since human fetuses can hear outside sounds at around 27 weeks, the findings suggest they’re also learning as they listen.

The authors say these results may lead to interventions that prevent future language impairments and help compensate for genetic disorders such as dyslexia.

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Gamelan Meditation with Jay Gullo

Thursday, April 29th, 2010

Gamelan Meditation with Jay Gullo
(live music)

Friday, June 11 at 7:00 pm

Location:
Creative Healing Arts
1568 McDaniel Drive
West Chester, PA 19380
(in the Westtown Business Center at Routes 3 and 352)
Please register by contacting us at
Createandheal@yahoo.com
or
610-738-0988

$15 a person
(Space is limited so please register early. Thank you!)

Enjoy the profound benefits of this live performance. Jay Gullo, a meditation teacher for over 30 years, will have you experiencing inner peace through the hypnotic sound of the gamelan. Jay’s master of this
truly melodic instrument and his innovative “in the moment” music has a tranquil, healing effect for those who hear it and provides a unique experience for each session.

It’s an honor to have this experienced teacher and
mentor at Creative Healing Arts! Jay is also well
known for his practice as a medium and clairvoyant.

createandheal.com

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Spring Drum Circle in West Chester

Thursday, April 29th, 2010

FOR IMMEDIATE RELEASE

Spring Drum Circle at Creative Healing Arts

Friday, May 21 at 7:00 led by Jay Gullo

$15.00

Email or call Jeanie at 610-738-0988 or
Createandheal@yahoo.com

It’s time to relax, have fun and be in the
company of those who enjoy a sense of
community and creativity. And, what better
way to do this then to make music!
Jay Gullo, a professional musician, who has
facilitated drum circles for over fifteen years
will lead us in various rhythms throughout the
evening. No experience is necessary

Drum Circles are about participation, not performance.
Those of you who have hand drums, rhythm instruments, etc., please feel free to bring them. There will be drums and percussion instruments available for those who may need them.

FOR MORE INFO OR
Creative Healing Arts
1568 McDaniel Drive
West Chester, PA 19380
(in the Westtown Business Center at Routes 3 and 352)

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An Evening of Gamelan Meditation

Sunday, February 21st, 2010

Gamelan Meditation with Jay Gullo
(live music)
Friday, March 12 at 7:00 pm
Please register by contacting us at
610-742-3908 or createandheal.com

$15 a person

(Space is limited so please register early. Thank you!)

Enjoy the profound benefits of this live performance.
Jay Gullo, a meditation teacher for over 30 years, will
have you experiencing inner peace through the
hypnotic sound of the gamelan. Jay’s master of this
truly melodic instrument and his innovative “in the moment”
music has a tranquil, healing effect for those who hear it
and provides a unique experience for each session.

It’s an honor to have this experienced teacher and
mentor at Creative Healing Arts! Jay is also well
known for his practice as a medium and clairvoyant.

Share